A2: Microbes in the News Post 2

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Copycat fungus deceives immune system and deactivates body’s response to infection. Science Daily, March 28, 2019.

https://www.sciencedaily.com/releases/2019/03/190328150745.htm

Summary: Cryptococcus neoformans,  a fungi that is very dangerous for immune compromised people is able to send out a signal to weaken immune response. This pathway in humans is intended to prevent an overreaction by the immune system by effectively deactivating immune cells.

Connections: We are currently covering the immune system and pathogens in class.

Critical Analysis: I was interested in this story because we are currently covering the immune system in class. The story was written by a sight that regularly covers news in the science world. It was able to effectively turn what was a far more technical research paper into something most people can understand.

Would it be possible for a drug to block this pathway to bolster the immune system?

New technique provides a better understanding of bacteria evolution

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New technique pinpoints milestones in the evolution of bacteria
Results show bacterial genomes provide “shadow history’ of animal evolution.
Jennifer Chu, MIT News Office February 7, 2019

References

Danielle S. Gruen, J. M. (2019, January). Paleozoic diversification of terrestrial chitin-degrading bacterial lineages. BMC Evolutionary Biology, 19-34. Retrieved from https://bmcevolbiol.biomedcentral.com/articles/10.1186/s12862-019-1357-8

 

—  Summary:  Researchers from MIT have established organism relationships between fungi and bacteria by reviewing the gene for chitinase (an enzyme which helps to break down chitin). Their review of the mutations, and similarities across different species has allowed them to create an evolutionary tree which correlates microbial evolution with fungal evolution. They found that approximately 450 to 350 million years ago, diversification of three separate bacterial groups diversified as the result of gene transfer with a chitinase utilizing fungi. Below is the resulting evolutionary tree with the fungi identified by purple lines and bacteria with blue lines.

(Gruen, et al. 2019)

—  Connections:  This connects with: Microbial evolution, metabolism, and diversification.
Chitinase allows these bacteria to metabolize chitin as an energy source. This allowed diversification of microbes into new niches ones chitin became more prolific in the environment. Gene transfer was said to make it difficult to genomically identify or differentiate bacterial strains, but here the gene transfer has allowed a better understanding.

—  Critical analysis: I found this article very interesting because, most evolutionary trees are based on rRNA sequencing (highly conserved due to form/function). The use of chitinase to correlate evolutionary relationships between fungus and bacteria is interesting. Especially since the origin of chitinase was in a Fungi (a microorganism that doesn’t look like a microorganism) and the gene has been horizontally transferred to bacteria.

The story was very well written and after reading the original journal publication, it was factually and accurately written. The author did as great job in conveying the information to the general population without losing the integrity of the research. I appreciate the writing style and how it helps those (like myself) who aren’t as well versed in the scientific nomenclature, to understand the information and findings from the research.

 

—  Question:  How many other highly conserved coding regions can we isolate and use in this manner? Are enzymes such as chitinase always highly conserved, or is there slight variations in the conformation, allowing it to mutate without ruining the function of the enzyme?

-Samantha Smith

Assignment 2 Microbes in The News

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How a Fungus can Cripple your Immune System

February 8, 2019

Source: Science Daily:  Friedrich-Schiller-Universitaet Jena

https://www.sciencedaily.com/releases/2019/02/190208095614.htm

Summary:

In this article the scientists conduct a study about how the fungus  Aspergillus fumigatus  is able to turn off an enzyme that is used by immune cells to communicate between each other. Healthy individuals are not very affected by the fungus, but it is dangerous to individuals who are immune difficient, such as individuals who suffer from AIDs.

Connection:

This does connect to when we were explaining what makes a microorganism. We discussed that fungi are covered under microorganisms, but we haven’t touched on fungus too much. This is a special adaptation specific to this type of microorganisms.

Critical Analysis:

I found this article very interesting in the fact that we often tell people that breathing in a certain fungus can “take years off your life’ and this fungus actually can. I learned to the extent that fungus can actually do this, I think people often assume that the air they breathe is healthy as long as it looks and smells pure, but this fungus has spores that can float through the air and be completely undetectable. I did not realize how potentially dangerous fungi can be, and it kind of opens your eyes to how vigilant people who have immune difficiencies have to be about their health.

Question:

How can we protect people who have immune defficiencies from these type of problems?

 

 

 

A2: Microbes in the News Assignment

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Microbes in the News !

Over the course of the semester, post 3 different stories involving microbes  from the popular media and then read and comment on 3  posts by other students.

 

Points: Total possible = 30 points. Earn up to 8 pts for making a post and 2 points for posting a comment. Create 3 posts and 3 comments over the course of the semester.

Deadlines: Posts can be made as soon as you’d like, but for full credit you must post them by these deadlines:

Post 1: Feb. 8

Post 2: April 1

Post 3: April 15

All comments: April 15

 

Learning Objectives:

– Increase your awareness of microbiology and its role in society

– Expand and apply your knowledge of microbiology

– Practice critical thinking by analyzing popular news media for scientific accuracy

– Develop questions about microbiology

– Help your peers and yourself understand microbiology by answering their questions

 

Instructions:

Over the course of the semester, create 3 separate Microbes in the News posts on the course website, and then read and comment on 3 Microbes in the News posts by other students. Be sure to follow the guidelines below in order to qualify for  full credit.

 

Guidelines for creating a post:

– Article and link: Enter the title, source, and date of the article and create a link to it. Articles should be from any popular media source (newspaper, magazine, podcast, blog,  etc.) that others can access without hitting a paywall. Any relevant story is acceptable, but challenge yourself to find stories that are current (~within the last 3 months) and that haven’t yet been posted by your peers, whenever possible.

– Summary: Write a short summary of the story (just a few sentences is sufficient).

– Connections: Explain briefly how this connects to what we’ve covered in class.

– Critical analysis: Explain what you found interesting about this story, and what (if anything) you learned. Comment on whether you think the story was scientifically accurate or not. If you noticed any factual inaccuracies or aspects of the story that might inadvertently confuse or misinform readers, identify those and provide a more accurate explanation. Also comment on how this was written. Do you think it did a good job of communicating science to the public? Why or why not?

– Question: Write a question about microbiology that you had as a result of reading this story.

– Categorize: Categorize your post as “A2: Microbes in the News’ using the categories menu on the right. This will ensure I can find it and give you credit.

– Tag: Tag your post based on any relevant microbiological themes by choosing from the tag menu (below categories on the right). Use existing tags when possible, but you can add new ones if needed by clicking “+Add New Category’ link just below the list of tags. This will help us find stories on relevant themes. You can also use these tags to search for other students’ stories on themes that interest you.

Guidelines for commenting on a post:

– Read the news story and the students’ post about it

– Create a comment and write a response to their critical analysis. Do you agree, disagree, or have more to add?

– In your comment, answer their question to the best of your ability. This might require some independent research.